Multiple Polyposis Coli - Erler Zimmer

Multiple Polyposis Coli - Erler Zimmer

Clinical History

No specific details of the clinical history are available for this case.

Pathology

The specimens in this case consist of two segments of the sigmoid colon. The bowel's mucosa is adorned with numerous sessile and pedunculated partially pigmented polyps, each reaching up to 1.5 cm in maximum diameter. There is no macroscopic evidence indicating malignant transformation.

Further Information

Under microscopic examination, the polyps predominantly exhibit a tubular adenoma structure (over 75% are tubular, also known as adenomatous polyps). Less frequently, they may present as villous adenomas (over 75% with villous morphology) or tubulovillous adenomas (25-75% villous). These polyps can display varying grades of dysplasia, and their histological features closely resemble sporadic colonic adenomas.
Patients diagnosed with familial adenomatous polyposis (FAP), a hereditary colon cancer syndrome linked to the APC gene on chromosome 5q21, are advised to undergo prophylactic colectomy. In this condition, invasive adenocarcinoma is almost certain to develop in one or more polyps, typically around 15 years after adenomatosis onset. FAP is inherited as an autosomal dominant trait.