Glioma grade 3-4, causing papilloedema - Erler Zimmer

Glioma grade 3-4, causing papilloedema - Erler Zimmer

Clinical History

A 24-year-old female initially presented with an abnormal electroencephalogram (EEG) following a single epileptic fit. Subsequent complaints of blurred vision and headaches led to the discovery of bilateral papilloedema during ophthalmoscopy, with no localizing signs to explain it. Further investigations revealed a space-occupying mass, later histologically diagnosed as a Grade III-IV glioma. The patient underwent radiotherapy, but a month into treatment, she developed weakness in the left arm and leg. Admission with drowsiness and vomiting ensued, culminating in rapid death.

Pathology

The specimen exhibits a large intracerebral lesion that has obliterated the lateral ventricles and the inner two-thirds of the internal capsule and basal ganglia on the right side. Infiltrating across the corpus callosum and distorting the aqueduct, the tumor displays a fairly well-demarcated, vascular nature with numerous areas of hemorrhage and necrosis, resulting in a mottled and variegated appearance.